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<i>Diospyros nigra<_i> (J.F.Gmel.) M.R.Almeida

" in MedChemExpress (MCE) Product Catalog:

By Targets:	HIF/HIF Prolyl-Hydroxylase (1) Mitochondrial Metabolism (2) Tyrosinase (2) VEGFR (1) α-synuclein (2)
By Research Areas:	Cancer (2) Inflammation/Immunology (1) Metabolic Disease (2) Neurological Disease (4)

Inhibitors & Agonists

Screening Libraries

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-121227

Cylindrin

Others Others

Cylindrin is a natural product that can be found in Diospyros nigra .
HY-N12541

Morunigrol C

Others Inflammation/Immunology

Morunigrol C is a compound that can be isolated from the barks of Morus nigra .

Cylindrin	Others	Others
Cylindrin is a natural product that can be found in Diospyros nigra .

Morunigrol C	Others	Inflammation/Immunology
Morunigrol C is a compound that can be isolated from the barks of Morus nigra .

HY-N10330

7-Hydroxyneolamellarin A	HIF/HIF Prolyl-Hydroxylase VEGFR	Cancer
7-Hydroxyneolamellarin A is a natural product that could be derived from sponge Dendrilla nigra. 7-Hydroxyneolamellarin A is a potent hypoxia-inducible factor-1α (HIF-1α) inhibitor. 7-Hydroxyneolamellarin A attenuates the accumulation of hypoxia-inducible factor-1α (HIF-1α) protein and inhibits vascular epidermal growth factor (VEGF) transcriptional activity. 7-Hydroxyneolamellarin A can be used in research of cancer .

HY-133593

Palustric acid

Others Others

Palustric acid is a diterpenic resin acid found in Pinus nigra .
HY-N12157

Noratherosperminine

Others Others

Noratherosperminine is an alkaloid that can be isolated from the stem bark of Cryptocarya nigra .
HY-N8994

3-Hydroxy-4',5-dimethoxystilbene

Others Cancer

3-Hydroxy-4',5-dimethoxystilbene is a natural compound found in stem bark of Morus nigra L .
HY-N11471

Steppogenin-7,4'-di-O-β-D-glucoside

Others Others

Steppogenin-7,4'-di-O-β-D-glucoside is a natural product that can be isolated from the roots of Morus nigra .
HY-N11476

5,7-Dihydroxycoumarin 7-O-β-D-glucopyranoside

Others Others

5,7-Dihydroxycoumarin 7-O-β-D-glucopyranoside is a natural product that can be isolated from the roots of Morus nigra .

Palustric acid	Others	Others
Palustric acid is a diterpenic resin acid found in Pinus nigra .

Noratherosperminine	Others	Others
Noratherosperminine is an alkaloid that can be isolated from the stem bark of Cryptocarya nigra .

3-Hydroxy-4',5-dimethoxystilbene	Others	Cancer
3-Hydroxy-4',5-dimethoxystilbene is a natural compound found in stem bark of Morus nigra L .

Steppogenin-7,4'-di-O-β-D-glucoside	Others	Others
Steppogenin-7,4'-di-O-β-D-glucoside is a natural product that can be isolated from the roots of Morus nigra .

5,7-Dihydroxycoumarin 7-O-β-D-glucopyranoside	Others	Others
5,7-Dihydroxycoumarin 7-O-β-D-glucopyranoside is a natural product that can be isolated from the roots of Morus nigra .

HY-N3516

Oxyresveratrol 2-O-β-D-glucopyranoside	Tyrosinase	Metabolic Disease
Oxyresveratrol 2-O-β-D-glucopyranoside is a phenolic compound isolated from Morus nigra root and is an effective tyrosinase inhibitor with an IC₅₀ of 29.75 μM .

HY-N3517

Oxyresveratrol 3'-O-β-D-glucopyranoside	Tyrosinase	Metabolic Disease
Oxyresveratrol 3'-O-β-D-glucopyranoside is a phenolic compound isolated from Morus nigra root and is an effective tyrosinase inhibitor with an IC₅₀ of 1.64 μM .

HY-W008719

MPP+ iodide 5+ Cited Publications	Mitochondrial Metabolism	Neurological Disease
MPP+ iodide, a toxic metabolite of the neurotoxin MPTP, causes symptom of Parkinson's disease in animal models by selectively destroying dopaminergic neurons in substantia nigra. MPP+ iodide is taken up by the dopamine transporter into dopaminergic neurons where it exerts its neurotoxic action on mitochondria by affecting complex I of the respiratory chain. MPP+ iodide is also a high affinity substrate for the serotonin transporter (SERT) .

HY-W008719S

MPP+-d3(iodide)	Mitochondrial Metabolism	Neurological Disease
MPP+-d₃ (iodide) is deuterium labeled MPP+ (iodide). MPP+ iodide, a toxic metabolite of the neurotoxin MPTP, causes symptom of Parkinson's disease in animal models by selectively destroying dopaminergic neurons in substantia nigra. MPP+ iodide is taken up by the dopamine transporter into dopaminergic neurons where it exerts its neurotoxic action on mitochondria by affecting complex I of the respiratory chain. MPP+ iodide is also a high affinity substrate for the serotonin transporter (SERT)[1][2].

HY-120475

PBT434 ATH434	α-synuclein	Neurological Disease
PBT434 is a potent, orally active and cross the blood-brain barrier α-synuclein aggregation inhibitor. PBT434 can be used as a iron chelator and modulates transcellular iron trafficking. PBT434 inhibits iron-mediated redox activity and iron-mediated aggregation of α-synuclein. PBT434 prevents the loss of substantia nigra pars compacta neurons (SNpc). PBT434 has the potential for the research of Parkinson’s disease (PD) .

HY-N10758

Petunidin 3-rutinoside

Others Others

Petunidin 3-rutinoside is a natural product that can be isolated from Sambucus canadensis .

Petunidin 3-rutinoside	Others	Others
Petunidin 3-rutinoside is a natural product that can be isolated from Sambucus canadensis .

HY-120475A

PBT434 mesylate ATH434 mesylate	α-synuclein	Neurological Disease
PBT434 methanesulfonate is a potent, orally active and cross the blood-brain barrier α-synuclein aggregation inhibitor. PBT434 methanesulfonate can be used as a iron chelator and modulates transcellular iron trafficking. PBT434 methanesulfonate inhibits iron-mediated redox activity and iron-mediated aggregation of α-synuclein. PBT434 methanesulfonate prevents the loss of substantia nigra pars compacta neurons (SNpc). PBT434 methanesulfonate has the potential for the research of Parkinson’s disease (PD) .

Anti-Parkinson's Disease Compound Library	1339 compounds
Parkinson’s disease (PD), the second most common age-associated neurodegenerative disorder, is characterized by the loss of dopaminergic (DA) neurons and the presence of α-synuclein-containing aggregates in the substantia nigra pars compacta (SNpc). Motor features such as tremor, rigidity, bradykinesia and postural instability are common traits of PD. To date, there is no treatment to stop or at least slow down the progression of the disease. The etiology and pathogenesis of PD is still elusive, however, a large body of evidence suggests a prominent role of oxidative stress, inflammation, apoptosis, mitochondrial dysfunction and proteasome dysfunction in the pathogenesis of PD. MCE offers a unique collection of 1339 compounds with anti- Parkinson’s Disease activities or targeting the unique targets of PD. MCE Anti- Parkinson's Disease Compound Library is a useful tool for exploring the mechanism of PD and discovering new drugs for PD.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-121227

Cylindrin	Triterpenes Structural Classification Terpenoids Ebenaceae Diospyros nigra (J.F.Gmel.) M.R.Almeida Source classification Plants	Others
Cylindrin is a natural product that can be found in Diospyros nigra .

HY-N12541

Morunigrol C	Structural Classification Source classification Morus nigra Linn. Phenols Polyphenols Plants Moraceae	Others
Morunigrol C is a compound that can be isolated from the barks of Morus nigra .

HY-N10330

7-Hydroxyneolamellarin A	Structural Classification Animals Source classification Phenols	HIF/HIF Prolyl-Hydroxylase VEGFR
7-Hydroxyneolamellarin A is a natural product that could be derived from sponge Dendrilla nigra. 7-Hydroxyneolamellarin A is a potent hypoxia-inducible factor-1α (HIF-1α) inhibitor. 7-Hydroxyneolamellarin A attenuates the accumulation of hypoxia-inducible factor-1α (HIF-1α) protein and inhibits vascular epidermal growth factor (VEGF) transcriptional activity. 7-Hydroxyneolamellarin A can be used in research of cancer .

HY-133593

Palustric acid	Structural Classification other families Classification of Application Fields Ketones, Aldehydes, Acids Source classification Other Diseases Plants Disease Research Fields	Others
Palustric acid is a diterpenic resin acid found in Pinus nigra .

HY-N12157

Noratherosperminine	Structural Classification Alkaloids Other Alkaloids Source classification Plants Lauraceae Cryptocarya nigra Kosterm.	Others
Noratherosperminine is an alkaloid that can be isolated from the stem bark of Cryptocarya nigra .

HY-N8994

3-Hydroxy-4',5-dimethoxystilbene	Monophenols Stilbenes Classification of Application Fields Source classification Morus nigra Linn. Phenols Plants Moraceae Disease Research Fields Cancer	Others
3-Hydroxy-4',5-dimethoxystilbene is a natural compound found in stem bark of Morus nigra L .

HY-N11471

Steppogenin-7,4'-di-O-β-D-glucoside	Structural Classification Flavonoids Flavonones Source classification Morus nigra Linn. Plants Moraceae	Others
Steppogenin-7,4'-di-O-β-D-glucoside is a natural product that can be isolated from the roots of Morus nigra .

HY-N11476

5,7-Dihydroxycoumarin 7-O-β-D-glucopyranoside	Structural Classification Natural Products Source classification Morus nigra Linn. Plants Moraceae	Others
5,7-Dihydroxycoumarin 7-O-β-D-glucopyranoside is a natural product that can be isolated from the roots of Morus nigra .

HY-N3516

Oxyresveratrol 2-O-β-D-glucopyranoside	Stilbenes Classification of Application Fields Source classification Phenols Polyphenols Metabolic Disease Plants Moraceae Disease Research Fields Morus alba Linn.	Tyrosinase
Oxyresveratrol 2-O-β-D-glucopyranoside is a phenolic compound isolated from Morus nigra root and is an effective tyrosinase inhibitor with an IC₅₀ of 29.75 μM .

HY-N3517

Oxyresveratrol 3'-O-β-D-glucopyranoside	Structural Classification Classification of Application Fields Polygonaceae Whitening Agent Source classification Reynoutria japonica Houtt. Metabolic Disease Plants Stilbenes Phenols Polyphenols Cosmetic Research Disease Research Fields	Tyrosinase
Oxyresveratrol 3'-O-β-D-glucopyranoside is a phenolic compound isolated from Morus nigra root and is an effective tyrosinase inhibitor with an IC₅₀ of 1.64 μM .

HY-N10758

Petunidin 3-rutinoside	Structural Classification Anthocyans Sambucus canadensis L. Flavonoids Caprifoliaceae Source classification Plants	Others
Petunidin 3-rutinoside is a natural product that can be isolated from Sambucus canadensis .

Cat. No.	Product Name	Chemical Structure

HY-W008719S

MPP+-d3(iodide)
MPP+-d₃ (iodide) is deuterium labeled MPP+ (iodide). MPP+ iodide, a toxic metabolite of the neurotoxin MPTP, causes symptom of Parkinson's disease in animal models by selectively destroying dopaminergic neurons in substantia nigra. MPP+ iodide is taken up by the dopamine transporter into dopaminergic neurons where it exerts its neurotoxic action on mitochondria by affecting complex I of the respiratory chain. MPP+ iodide is also a high affinity substrate for the serotonin transporter (SERT)[1][2].

MPP+-d3(iodide)

MPP+-d₃ (iodide) is deuterium labeled MPP+ (iodide). MPP+ iodide, a toxic metabolite of the neurotoxin MPTP, causes symptom of Parkinson's disease in animal models by selectively destroying dopaminergic neurons in substantia nigra. MPP+ iodide is taken up by the dopamine transporter into dopaminergic neurons where it exerts its neurotoxic action on mitochondria by affecting complex I of the respiratory chain. MPP+ iodide is also a high affinity substrate for the serotonin transporter (SERT)[1][2].

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